8 thoughts on “C43 – Howe

  1. Hi Tyler,

    Great presentation. I did have a question about the future therapeutic advantages of RRM2. Specifically, how does RRM2 detect and activate the regrowth of damaged DNA.

    1. Hi! Rrm2 doesn’t itself detect or activate regrowth of damaged DNA. Rrm2 codes for a subunit of the ribonuclease reductase, which converts ribonucleotides to deoxyribonucleotides. We hypothesize that this process is involved in the overall DNA damage repair process.

    1. We could most likely run knockout tests to determine what happens when we remove Rrm2 within the cell, as well as compare it to other similar genes when knocked out.

  2. This was a great presentation!
    Do you see any potential issues using RRM2 to address DNA damage?

    1. We do not see any issues, as Rrm2 is a natural gene within the human body that codes for the subunit of an important enzyme for cellular function!

  3. Hi Tyler, fantastic job with your presentation! In your future directions, you mention tests would be necessary to determine exactly how Rrm2 functions in the repair of DNA, I am wondering if you have any ideas or theoretical plans for how this could be done, or if it required technology that you don’t have access to?

    1. Hi! We in the research lab we were a part of do not have access to the required tech, but we would guess that methods such as gene knockout could help in determining the function of Rrm2!

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