6 thoughts on “C48 – Muth

  1. Hey Sara,

    Great presentation! During the DNA repair process, is homologous directed repair always utilized? Or can nonhomologous end joining be utilized as well?

    1. Referring to the DNA repair process in general, homologous recombination is just one of the ways that DNA can be repaired. Nonhomolgous end joining is also a great tool that is used by eukaryotes as well. It is a more error prone process though.

  2. Great presentation! If RCF1 isn’t a likely option for cancer developments do you think it will have other possible applications? Could it be used in genetic disorder research possibly?

    1. Considering cancer is a very complex disease, it may theoretically still be a possible tool in cancer research. Errors in homologous recombination are just one of the ways that cancer can occur. In the context of homologous recombination and cancer, it’s not a great candidate for further research. If it does function as a clamp loader, it is possible that it may be used in genetic disorder research because dysfunction of a clamp loader may cause issues with DNA replication. So overall, I think it may be useful to study in genetic disorders.

    1. I think it would be challenging to definitively answer that question at this time because we do not yet know what Rfc1’s function is. Once the function of the protein is known, that could narrow the possibilities.

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