11 thoughts on “C80 – Stoner

  1. What medical conditions caused by DNA damage could be treated with SetK, and how would it be used in clinical applications?

    1. Currently as it stands, there is still not much known about SetK. The one big thing that we really just learned was that it is most likely involved in DNA damage repair. To fully understand what SetK is doing within DNA damage repair will need some more future experimentation.

  2. What experiment would you do to determine how much of an affect SetK has on DNA damage repair compared to other DNA repair mechanisms?

    1. One thing we could do for future experimentation is completely remove the gene from the genome of T. thermophila. This would allow us to observe the cell, under DNA damage, without the SetK protein. Any abnormalities that can be observed could mean that SetK has a large impact on the DNA damage repair response of the cell.

  3. What experiments would you do in the future to further prove that SetK can be used for clinical use?

    1. A threonine/kinase protein is mainly a kinase (an enzyme that phosphatases) that phosphorylates the amino acid threonine. The protein has been observed to play a role in apoptosis and cell differentiation. One thing that is known about the protein is how it can be involved in cell signaling, and so future experimentation would allow us the determine if SetK is a DNA damage signal protein.

  4. It was a little difficult to visualize your experiment and methods without a clear picture of your model organism, so I’m curious what T. Thermophila is?

    1. T. Thermophila is a eukaryotic cell that is extensively used for the study of things such as DNA damage. T. Thermophila is incredibly useful as whenever it mates, it intentionally induces its own DNA damage, also making it good at repairing its own DNA. Knowing that T. Thermophila has really good built-in DNA damage repair processes, it makes it easy to compare other repair proteins to already preexisting ones.

  5. What are your opinions about SetK’s effectiveness and what do you think is a realistic time scale of it being used in medical practices?

    1. It was shown that SetK is most likely to have a purpose within the DNA damage repair process. It is hard to say a specific time scale as the function of SetK still has yet to be known. Determining whether or not SetK has a big or small impact on the DNA damage repair process is very important to know. If SetK has a big impact on DNA damage repair, it is definitely something that will want to get some more attention, especially if it has the possibility of preventing the DNA damage induced by the developments of cancer.

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