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11 thoughts on “D10B – Vanleeuwen”
Do you think that an even higher dose of tetrandrine would have been more effective in killing cancer cells, or would that high of a concentration be toxic?
Yes, I think it’s possible that a higher dose would have been more effective in killing cancer cells. It would just have to be tested to see if it would be attainable to have a higher concentration in the bloodstream of patients, if it proved to be effective in killing cancer cells.
Yes, I think that it could be more effective in killing cancer cells. It would just need to be tested if it is attainable to reach a higher concentration of the compound in the blood stream of the patients.
how would A higher dose of tetrandrine affect the cancer cells?
I’m not positive, but I think that is a test that we would perform if we had more time in the lab. I think that increasing the dose of Tetrandine would show a lower percent survival in the third instar larvae.
Great presentation! What would the dosage curve you talked about tell you about this potential chemotherapy treatment?
The dosage curve would show that as the concentration of the compound is decreased or increased, it is able to control the percent survival of the third instar larvae. It could also show if our compound is actually toxic and a poison. For example, if the concentration was changed and the survival rate never changed, the compound could be a potential poison.
Great Presentation! You mentioned that there are flies which have a mutation that makes them more resistant to radiation. Will that mutation become more prevalent in the future and is it favorable for the fly?
Yes, there are flies that have a mutation called the grp mutation, which causes them to be more resistant to damage caused by radiation. I’m not sure if the mutation will become more prevalent in the future, but it is being used in research in Tin Tin Su’s Lab right now. I’m not sure if it is favorable for the fly in ways other than preventing as much DNA damage as wild type flies when exposed to radiation, but that is very favorable for them in the sense that they are more resistant from damage to their DNA.
Hi Emily! Nice work! I was wondering since fruit flies are so mutagenic, is it possible that the specific larvae for one of conditions had more mutations of cells during growth? Could this lead to one batch surviving better than another not because of the conditions they are in, but rather that they are more mutanegenic? How would one control for that (that is, if it even is a cause for concern)? Would you just need to repeat the experiment a lot?
I’m not quite sure what conditions could cause to more mutations in the flies. However, we would want to do more trials to see if there are certain flies with a mutation that could cause them to be resistant to Tetrandine as a chemotherapy or to the radiation. For example, the grp mutations in flies causes them to be more resistant to radiation and it is possible that there are more mutations that could lead to the flies being resistant to chemotherapies and radiation.