10 thoughts on “D14a – Tiller

  1. What are some of the major causes of antibiotic resistance? Can antibiotic resistance be prevented at all?

    1. some of the major causes of antibiotic resistance are over-prescription of antibiotics, not taking the antibiotics as prescribed, and overuse of antibiotics in livestock and farms (which will be in the meat that you eat). Antibiotic resistance can somewhat be prevented, by taking antibiotics correctly. However, some antibiotic resistance is random mutations, and that unfortunately can not be prevented.

    1. (I think the same person asked this question twice. I responded to the first one that asks the same question)

    1. So this experiment is just the beginning stages of testing to see if it could potentially be an effective antibiotic, but it does look promising. Before this antibiotic moves to human trials, there needs to be a lot further testing and possible animal testing. Some further research could be to test if the compound is bactericidal or bacteriostatic (kills or stops the growth of bacteria), and to see what happens when you use smaller and smaller doses and dilutions on Salmonella and if the absorbance keeps decreasing, or if it increases (a U shaped dose response curve).

    1. I am not sure why the lower doses are more effective, but it could potentially be because the compound is an endocrine receptor and shows a U shaped dose response curve. Although it is interesting to note that the lower doses were more effective, it is not all that uncommon, with 1000 other compounds showing a U shaped dose response curve.

  2. What would your first step be in testing this compound further? bactericidal or static as said or could it be something else?

    1. My first step in testing this compound further would be to test smaller doses and dilutions on Salmonella and figure out if this compounds shows a U shaped dose response curve or not. From there, we could then figure out if the compound is either bactericidal or bacteriostatic.

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