7 thoughts on “D16 – Greene

  1. Do you think that more repeated trials would change your results of this compound being a hit or not?

    1. Thank you for the question Nikhil–I can’t say for sure whether repeated trials would change the results and make the compound a hit. I think likely not just based on how far our compound was from being a hit, but a single experiment doesn’t provide great statistical power in being able to be confident about its status as a miss either. I think if anything repeated trials would give us a clearer sense of any patterns that emerge as a result of different dilutions of ginkgetin.

  2. In your background section, what exactly do you mean by combinatorial therapies? Some further details would help!

    1. Great question Manas–combinatorial therapies refer to cancer treatments that are given in combination (such as giving a patient both radiation and chemotherapy) instead of a single treatment alone. The advantage of combinatorial therapies is that sometimes multiple therapies can have a synergistic effect, meaning that the result effect is greater than the additive effect of each therapy on its own. This effect can also mean a reduced impact of toxicity associated with a larger single dose of one type of therapy, which is one of the things that makes cancer so difficult to treat.

    1. Thanks for the question Tanner–we were irradiating larvae of the common fruit fly, which was our model organism that serves as a model for cancerous tumor cells. We irradiated the larvae to mimic the radiation used in cancer treatment.

  3. Chemotherapeutic therapy is known to kill the tumor cells with an impairment of the immune system, so are there benefits of using ginkgetin that will reduce such repercussions?

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