15 thoughts on “D23B – Fowler

  1. Can you explain a bit more about the Allicin not being a radiation sensitizer. What does this exactly mean?

    1. Absolutely. So the idea is that the percent survival of the compound with radiation would be lower than if the percent survival of the compound without radiation and the percent survival of the negative control with radiation was added together. So it would be a synergistic effect rather than an additive effect.

    1. Absolutely. So the idea is that the percent survival of the compound with radiation would be lower than if the percent survival of the compound without radiation and the percent survival of the negative control with radiation was added together. So it would be a synergistic effect rather than an additive effect.

    2. So in previous studies it has been shown to induce apoptosis in glioma cells and carcinoma cells. Given that it acted as a potential chemotherapy in cells, this made it promising for research at the organismal level!

    1. In the past they have been shown to respond to known chemotherapies as cancer cells would. They are also cheap and easy to raise.

    1. For our main study we used 2 mg/mL. This is the concentration that we know can be diluted into the body successfully.

    1. Well this means that it acts as a potential chemotherapy since it was toxic to an organism which models cancer cells.

    2. Well this means it is a potential chemotherapy since it was toxic to an organism which models cancer cells.

  2. What does it mean that Drosophila Larvae respond accurately to known chemo-therapies? Is this determined experimentally?

    1. It responded to known chemotherapies in a way that would be expected of cancer cells. This was determined partially by accident in the Tin Tin Su laboratory. They found that a hit was discovered in a natural compound, and that natural compound was the basis for a known chemotherapy!

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