Hi Evan,
Thank you! I personally think it would be really interesting to replicate this use of proton pump inhibitors in animal cell lines, like mice or rats. However, these compounds would need a significant amount of testing in order to get to that point. Thank you for your question.
I would hope that in a synergistic experiment Omeprazole would have a similar response. It did show to be a chemotherapeutic (so it may show similar results) but it was not nearly as potent as the Pantoprazole.
Our two compounds were chemically similar to another FDA approved proton pump inhibitor that specifically focused on targeting carcinomas of the head and neck. Due to our drugs similarity to this FDA proton pump inhibitor I would hope our compounds may be successful in similar cancers.
Using irradiated larvae shows how our compound works with radiation and the non-irradiated larvae shows the use of the compound on its own. This experiment tested the synergistic effects of both the compounds and the radiation.
I think you gave a great bit of information on your presentation! I would like to know more background as to why you were using the model organism that you did?
I don’t know which model you are referring to either our drosophila or our compounds so I’ll explain both :). We chose the Drosophila Melanogaser because it is very inexpensive to reproduce and it has a life cycle of only 20 days plus it has a very high similarity between genes in humans. The compound models were chosen because they both focus on a major function of the cell and they both had similar chemical structures to another FDA approved proton pump inhibitor.
Hi Sarah,
Great Presentation! Do you know what type of cells you would like to work with in the future using Pantoprazole and Omeprazole?
Hi Evan,
Thank you! I personally think it would be really interesting to replicate this use of proton pump inhibitors in animal cell lines, like mice or rats. However, these compounds would need a significant amount of testing in order to get to that point. Thank you for your question.
For the irradiated vs. non-irradiated experiment, would you expect similar results from Omeprazole as Pantoprazole?
I would hope that in a synergistic experiment Omeprazole would have a similar response. It did show to be a chemotherapeutic (so it may show similar results) but it was not nearly as potent as the Pantoprazole.
Would you expect this treatment to be applicable to a specific type of cancer?
Our two compounds were chemically similar to another FDA approved proton pump inhibitor that specifically focused on targeting carcinomas of the head and neck. Due to our drugs similarity to this FDA proton pump inhibitor I would hope our compounds may be successful in similar cancers.
What was the purpose of using irradiated vs. normal larvae?
Using irradiated larvae shows how our compound works with radiation and the non-irradiated larvae shows the use of the compound on its own. This experiment tested the synergistic effects of both the compounds and the radiation.
I think you gave a great bit of information on your presentation! I would like to know more background as to why you were using the model organism that you did?
I don’t know which model you are referring to either our drosophila or our compounds so I’ll explain both :). We chose the Drosophila Melanogaser because it is very inexpensive to reproduce and it has a life cycle of only 20 days plus it has a very high similarity between genes in humans. The compound models were chosen because they both focus on a major function of the cell and they both had similar chemical structures to another FDA approved proton pump inhibitor.