7 thoughts on “D2C – Howe

  1. Hey, this was a really good presentation. Do you have any ideas as to why there seems to be an inverse dose response?

    1. We aren’t entirely sure why there is the inverse response! It can happen for a wide variety of reasons. Some drugs to tend to behave in this manner, such as endocrine disruptors like Bisphenol A – a dose-response curve of this would have a sort of “inverted U shape”. It is mainly just due to the chemical nature of the compound!

  2. What are some things you can do accomplish Phenazopyridine if it becomes a “true” hit, and what further testing does it require?

    1. Most further tests would be similar to the ones we conducted here – we would be looking to see how effective Phenazopyridine is as a chemotherapy in various model organisms. If it did show statistical promise, testing could begin on toxicity levels as well as the most effective dose (it isn’t always the highest dose!).

  3. For your future experiments, when considering different compounds to use what are some characteristics the compound must have and what compounds would you like to experiment with next( if applicable)?

    1. We selected our compounds because they showed structural similarity to two compounds that had shown promise in previous drug screens. We would be interested in taking a similar approach for any future compounds. Since 5-norbornene-2-carboxylic acid showed very little promise, we would be interested in researching compounds that show structural similarity to Phenazopyridine, as it was close to being a hit. PubChem is a super useful tool for this – you can search for compounds with similar structures to a chosen one.

  4. Wonderful presentation. I was wondering if you had any ideas as to why the results of your experiment ended up being the inverse of what you expected the values to be?

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