13 thoughts on “D4 – Lenoir

  1. Great Project! I would love to know a bit more about your compounds, what cellular pathways do your compounds directly effect?

  2. Great presentation! I would love to know a bit more about your compounds. What cellular pathways do you compounds directly effect?

    1. Thank you for your question! Capecitabine inhibts RNA synthesis (if you look at the structure on our poster, you will see that it’s structure ressembles that of a ribonucleoside!). Erlotnib is an inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor.

  3. Nice job! I was wondering if there was another reason you chose to test specifically those compounds together or if it was just since they have been used for cancer treatment before?

    1. Thank you for your question! Yes, the fact they are commonly used is what pushed us to test these: since they are already very useful, it would be great to find ways of decreasing the appearance of side effects.

  4. Very engaging research project. Your abstract and introduction were thorough and helped give a great background to your project. I thought that it was great that you explained the differences between the model organism and humans. Other than that, your results and discussions were great and very informative. It would have been nice for some of the fonts to be a little larger, the poster seemed filled with words, but I understand that you had to fit all of it somewhere. Overall, phenomenal job on the presentation and the project as a whole.

    1. Thank you for your kind words, it was an amazing research project to engage with. We’ll definitely make the font bigger next time, there was just so much we wanted to share!

  5. If more research was conducted, what other organisms would you test these compounds on before testing on humans?

    1. Thank you for your question! If a combinatorial effect was found in the drosophila model, the next step could be to test these compounds together in mammal organisms as it would be important to address safety issues before testing on humans (possible toxicities when administering these compounds together that don’t exist when administering them alone). For example, if this drug combinations turned out to be very toxic to mammal livers, this might be something we wouldn’t know from testing on drosophila.

  6. Nice job! You mentioned that the compounds used have been used for cancer treatment before but is there any other reason that you chose to specifically combine those compounds to test?

    1. Thank you for your question! The main reason was definitely the fact they are commonly used for cancer treatment as it would be great to find ways of decreasing the appearance of side effects. We also made sure, as best as possible, that the metabolic pathways disrupted by these compounds are present in some capacity in the drosophila model.

  7. Hi Henri! Good job on your poster and presentation! One thing I’m wondering about is do the two compounds have any specific impacts on each other that could have effected the results of the experiment?

    1. Thank you for your question! These two compounds affect very different pathways, and our results did not show any difference between using one, the other, or both together (though to be fair we probably suffered from a significant floor effect by probably not using high enough volumes). However metabolic pathways are obviously quite sophisticated and interconnected. When we are hoping for a synergestic effect, we are precisely hoping for an interaction between the two compounds that make them particularly effective (more so than just an additive effect). It would be great if future research could find such a synergestic effect, as that is typically ideal for reducing side effects. On the other hand, it is possible, though unlikely, that these compounds cancel each other’s effectiveness. The worst case scenario is if these compounds become extremely toxic to humans when given together, even is small doses.

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