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8 thoughts on “D64 – Apodaca”
How does the host range of ECG’S compare to the tests done on Salmonella, would ECG’s be able to kill other types of infections that are genetically similar to Salmonella?
There have been other tests done on gram negative bacteria (just like salmonella) using EGCg and it has been proven to have antimicrobial properties in those bacteria as well.
Super interesting that your compound worked better in smaller amounts! If there is a nutrient in it that promotes the growth of the salmonella, wouldn’t it still be present in the same ratio even if the dose changes? Are there any other possible reasons for your results?
We used a capsule of EGCg and it wasn’t pure EGCg, so we believe that there could have been a compound within that capsule that served as a nutrient to Salmonella. Since we don’t know the exact amount of EGCg that each of the wells got, it’s hard to say whether or not each well got the same amount of EGCg and the same amount of “nutrient”
In your future directions you say a next step could be to “alter the shape of the compound”, what exactly do you mean by that?
Altering the functional groups can alter the function of the compound. We’re hoping that using medicinal chemistry will increase the antimicrobial properties in the compound and decrease the nutrients ”feeding” the salmonella.
Great job! In the dose response curve, was the value for EGCg at 0.15625 mg/mL statistically significant?
As the concentration in 1:2 serial dilution series decreases so should the antimicrobial properties but that doesn’t happen here. We consider 0.15625 statistically significant because that’s where the antimicrobial properties were lost.