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9 thoughts on “D70 – Avdem”
Great presentation! Where are these short amino acid sequences with antimicrobial properties usually found?
Thank you! These sequences are found in several proteins around the world; they are actually very common! The specific CAMPs we were examining were found originally in the Komodo dragon genome!
Great job! Are there any potential modifications you could make to the compound that would potentially make it more effective against salmonella?
Thank you so much! Since we determined that our specific peptide was ineffective at treating S. Typhimurium, the only modifications we would propose are adding it to another peptide sequence or altering the media used for growth. Our next steps however would most likely be to examine different sequences and evaluate them for antibiotic properties!
Great job! Are there any potential modifications you could make to the compound to make it more effective against salmonella?
Great presentation!! What role did your group have in picking the peptides you used, as you mentioned they were picked using an algorithm?
Thank you! Our group played only a role in narrowing down the type of sequence we wanted. The peptide was determined algorithmically, however our group was very specific about the characteristics we were looking for (alpha helical in structure, amphipathic, and positively charged). Our group determined these characteristics and then a peptide was selected from a small library (about 14) of peptide sequences.
Great job! What led your group to decide the peptides you had used ?
Thank you! Our group was able to narrow down peptide sequences by selecting peptides with three distinct characteristics: they are positively charged, alpha-helical in structure, and amphipathic. These characteristics are important to the peptides ability to act as an antibiotic. By using this criteria, a library of potential peptide sequences was created, and a sequence was chosen and ran through an I-Tasser program to ensure it is likely to meet these criteria.