8 thoughts on “D75 – Veeranki

  1. Good job Sindhu! Why do you think your dosage series showed similar survival for all doses?

    1. Thanks Delwin! Our dosage series likely showed similar survival for all doses because the compound, Phospholipase A2, is likely not able to result in lower survival rates, regardless of concentration used. This indicates that the compound would likely not be able to be used as a potential chemotherapeutic, as it does not act synergistically or additively with radiation to kill rapidly dividing cells.

    1. Thanks Ellie! Fruit flies are commonly used as model systems because they are easy and inexpensive to maintain in the lab. The life cycle of the fly is around 10 days, which means experiments are quick to produce results. In our research specifically, we use the third instar larvae of the fruit flies because the growth rate of the larvae has a rapid growth rate, similar to the growth rate of cancer cells.

    1. The wild type flies (used in this experiment) are actually the flies that have a known resistance to radiation. These mechanisms are not fully understood and further research is done to understand why.

  2. Great Job! Why do you believe that the data and your results didn’t end up supporting your original hypothesis.

    1. Thanks Sophia! The results showed that the percent survival rates of the maximum dose of the compound, along with dilutions, did not produce a low enough survival rate to be identified as a potential chemotherapeutic. This was identified because the survival rates from the compound were not 2 standard deviations below the mean of the negative control.

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