11 thoughts on “D79 – Long

  1. Do you have any general idea of what type of drugs to start new testing with that might be radiation resistant, or is that still a big unknown in cancer research?

    1. Hi William,

      There are a couple of radiation protectors already on the market and they’re often used to prevent further radiation damage in those who are at risk for further DNA damage. One of the examples that comes to mind is when the FDA recommended in the event of a radiation emergency, people take potassium iodide to protect against thyroid cancer.

  2. For the future directions, what would be the benefits of going the long-term perspective route rather than the short-term?

    1. Hi Luke,

      Both would be beneficial, by looking at the effects of Methiothepin Maleate more broadly in different clinical applications we can find different uses for it as a drug. It is a serotonin agonist and could potentially be used in the neurological setting further research is required. In the short-term however, it would be nice to run more trials to see if Methiothepin Maleate can in fact be used as a radiation protector. The major limitation of this experiment was that we didn’t have a lot of trials to actually see proper results so in the short-term just having more trials would be great to see maybe if the data changes at all and leads to a different conclusion.

  3. For the future directions, what would be the benefit of going the long-term perspective route rather than the short-term perspective?

    1. Hi Whit,

      In terms of future directions the goal would be to find new applications for Methiothepin Maleate in the clinical setting. What may be a good start is to look at the neuroscientific properties of MET because it is a serotonin agonist and thus could be used possibly in treatments of depression or other mental illnesses with a basis in neurology.

  4. What kind of experiment would you design to determine the broader clinical application and effectiveness of MET?

    1. Hi Carole,

      After some determination of clinical safety it would be interesting to see experimentation on rodents to assess their activity with serotonin receptors. MET is a serotonin agonist so looking at neurological applications could be beneficial.

    1. Hi Murphy,

      Traditionally radiation protectors are used to protect those at risk for developing future cancers or DNA damage. They can be used to help those who have had cancer such as skin cancer and need protection from UV radiation, they are used in the case of HIV and AIDS and other inflammatory disorders. More broadly though, their purpose is to prevent the damaging effects of radiation.

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