10 thoughts on “D82 – Cramer

  1. What are some strategies that could be implemented to mass produce this cancer drug if it were proven to be successful?

    1. Considering this is already a FDA approved drug for treating leprosy and certain neck and head cancers, I believe it is being mass produced. I’m not sure how I would be able to mass produce it besides going through additional screenings to approve it for other cancers as well.

  2. Do you think it would be beneficial to trial this drug on more closely related organisms to that of humans?

    1. I believe it would be beneficial but I don’t believe it is ethical to since fruit flies mimic a lot of cell functions in the human body such as the Chk1 kinase. This drug is FDA approved so it likely was already tested on organisms closer to humans.

  3. Although the clofazimine did not kill the larvae more effectively, did the data indicate it could work as a raditation protectant? Or do you think in the future it would work better for killing cancer kills tested in vitro?

    1. As mentioned in the results and conclusion section, yes the data potentially indicates that Clofazimine could protect against radiation because it had incredibly high survival rates when in combination with radiation. As well, in vitro testing would allow for us to see more biological phenomena that occurs in specific cells or genes such as the Wnt gene.

  4. Do potential chemotherapeutic treatments often have the potential to be radiation protectors as Clofazimine does?

    1. I am not sure. Based on the research we have conducted and the information we have been given in class, the most effective way for radiation protection is by conducting radiation treatments periodically. I do think there is potential for certain chemotherapeutics to protect against radiation if they yield a high survival rate.

  5. Despite not being useful as a chemotherapeutic treatment, could Clofazimine be used as radiation protectant? If so how would you test for its efficacy as a protectant?

    1. As mentioned in my conclusion I did state that Clofazimine could be used as a radiation protectant because of the survival rates. We could test this by having the dose of Clofazimine stay consistent and change the Rad per trial. This would allow us to see if survival rates remain around the same for each trial which would indicate Clofazimine protects the organisms against radiation.

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