Hey Jared, good question! Unfortunately, none of the previous research I looked at had any tests for determining bacteriocidal/static nature of ellagic acid of gram-negative bacteria.
Great presentation!! What kind of experiment would you conduct in order to identify the specific mechanisms in the acid that caused the bacteriostatic effects in your experiment?
That’s a great observation. My first thought is to test on other cells, perhaps other gram-negative bacteria to see if ellagic acid has the same static growth effect. Like I mentioned, I think testing a system with bacteria and macrophages might also be worth a try.
Thanks Kyle, great question! I don’t quite have the knowledge of cell biology to answer that question. That question is part of our future directions of researching ellagic acid, knowing the response in mammalian cells is crucial to understand.
Good question! I could imagine preventing replication of bacteria would be safer (for humans) than killing the organisms. That being said, bacteriostatic and bactericidal antibiotics are both very important in the fight against microbial drug-resistance.
Great presentation! Were any other acids compared to/tested alongside Ellagic, and do you think any of them have the potential to rival Ellagic acid’s effectiveness in treating salmonella?
Hi Lily, good question! Our group didn’t research any other compounds or acids as that would be outside of our scope for this project. It’d be worth studying the medicinal chemistry of ellagic acid and any similar compounds to compare the effectiveness, perhaps in future research.
Great presentation! Were any other similar acids compared to/tested alongside ellagic acid, and if so do you think any of them potentially rival ellagic acid’s effectiveness in regards to treating salmonella?
Hi Lily, good question! Our group didn’t research any other compounds or acids as that would be outside of our scope for this project. It’d be worth studying the medicinal chemistry of ellagic acid and any similar compounds to compare the effectiveness, perhaps in future research.
Hi Kyle, that’s a good question. While I don’t have very much knowledge of how drugs should be delivered, my guess is that ellagic acid could be delivered either orally or topically. Although, I’d lean toward oral treatment since there are already dietary supplements containing ellagic acid.
Did other research show that ellagic acid was bactericidal or bacteriostatic for the other gram-negative bacteria tested?
Hey Jared, good question! Unfortunately, none of the previous research I looked at had any tests for determining bacteriocidal/static nature of ellagic acid of gram-negative bacteria.
Great presentation!! What kind of experiment would you conduct in order to identify the specific mechanisms in the acid that caused the bacteriostatic effects in your experiment?
That’s a great observation. My first thought is to test on other cells, perhaps other gram-negative bacteria to see if ellagic acid has the same static growth effect. Like I mentioned, I think testing a system with bacteria and macrophages might also be worth a try.
Great work, do you have any thoughts on how ellagic acid might negatively impact the host based on its effectiveness against the bacteria?
Thanks Kyle, great question! I don’t quite have the knowledge of cell biology to answer that question. That question is part of our future directions of researching ellagic acid, knowing the response in mammalian cells is crucial to understand.
Could there be a benefit to how Ellagic acid interrupts bacterial growth in the context of treatment?
Good question! I could imagine preventing replication of bacteria would be safer (for humans) than killing the organisms. That being said, bacteriostatic and bactericidal antibiotics are both very important in the fight against microbial drug-resistance.
Great presentation! Were any other acids compared to/tested alongside Ellagic, and do you think any of them have the potential to rival Ellagic acid’s effectiveness in treating salmonella?
Hi Lily, good question! Our group didn’t research any other compounds or acids as that would be outside of our scope for this project. It’d be worth studying the medicinal chemistry of ellagic acid and any similar compounds to compare the effectiveness, perhaps in future research.
Great presentation! Were any other similar acids compared to/tested alongside ellagic acid, and if so do you think any of them potentially rival ellagic acid’s effectiveness in regards to treating salmonella?
Hi Lily, good question! Our group didn’t research any other compounds or acids as that would be outside of our scope for this project. It’d be worth studying the medicinal chemistry of ellagic acid and any similar compounds to compare the effectiveness, perhaps in future research.
What would be an effective method of delivery for this treatment? Topical, oral, etc.
Hi Kyle, that’s a good question. While I don’t have very much knowledge of how drugs should be delivered, my guess is that ellagic acid could be delivered either orally or topically. Although, I’d lean toward oral treatment since there are already dietary supplements containing ellagic acid.