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10 thoughts on “D9C – Cofman”
Is it known why/how andrographolide shows such promise with apoptosis?
It gives more signals to regulate cell death initiation! Basically, a normal cell would not send out enough signals to keep a cancer cell in check, but with andrographolide it can send more. I am not sure on a molecular level though it would be interesting to look in to.
Good job on your poster. Do you think Andrographolide will work for other diseases other than cancer?
I think it could be really good for minimal things such as slight inflammation, anti-bacterial, and as an antioxidant, but would likely need something to work synergistically with it. It is already FDA approved so it can be used for things like that already! Alongside other things such as radiation in our case would possibly have more useful results.
Why specifically did you use third-instar larvae?
We use third instar larvae because that it the point in development when they are replicating the most. Therefore it will be the most realistic cancer model! Also, if we used all of them it would yield different results because many of them would take longer to turn into pupa.
Why do you think that the Andrographolide led to the activation of a pathway that caused the death of certain larvae at lower doses and what implications could this have for medical uses?
After talking to Dr. Harvey and our TA, we came to the conclusion that our compound has a U shaped curve. So basically at really low dosages and really high dosages the percent survival is lower. That means you can experiment with the dosages a little bit and could use the toxicity levels to change the use for other fields of medicine possibly. I am not sure about why this is, but could be tested further to see what kind of implications it may have!
Great poster and presentation. How does radiation work to increase the toxic effects of the drug? Does it just weaken the target further or is there something else going on?
Yes exactly! Our compound was able to weaken the cancerous cells and allow for the radiation to work better.