8 thoughts on “G14 – Orbidan

  1. Are there any other future directions you may want to explore other than statistical analysis/significance? How would you effectively update the annotated phage genomes, since this is such a massive project in a database containing thousands of phage?

    1. Thanks for your question Savannah! The only other note-able thing I think that I could move further with this research other than a statistical analysis would likely be try to determine if there is a relationship between these two units and the presence of other genes/proteins. I.e., is there some unique relationship between the LTS and STS and perhaps the Capsid Maturation Protein? Honestly, I feel like it opens a pandora’s box with more things to dive into. And in terms of updating the database, I think that would require submitting a formal proposition to the Phamerator folks as well as Phages DB, like with that aforementioned statistical analysis and show proof of concept of why I believe it should be updated. I personally do not have access to officially change things like that, that is above my pay grade.

  2. Hello Dan, as someone who is unfamiliar with the nomenclature of genetics, can you tell me a little bit about what a Pham is and how they are categorized? Great work! Thank you for sharing your research with us.

    1. Hi Kylie! Absolutely, sorry about that, I could only fit so much into five minutes. “Phams” is a term used to further categorize specific genes. Rhere is not just one type of large terminase subunit amongst phages, there is a diversity of them, and they are categorized as phams. I think a good example for humans is lets say the genes coding for hair color. Most people have the genes to code for specific hair color, but there is a diversity of the colors of hair, and those can be seen as the hair color phams, i.e. “blonde pham” vs “brown pham”. Hope that clears that up!

    2. My comment doesn’t show as posted here… let me try submitting this one to see if it works…

  3. Great job! You have some great findings. I was wondering if there is anything else you could do with your new knowledge?

    1. Hi Emery, thanks for your comment! Honestly, I mentioned earlier above, that I think this opens up a somewhat pandora’s box into future research endeavors, from statistical analysis, to continuing to try and refine the phage annotation protocols with this new found knowledge!

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