Share this:Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Like this:Like Loading...
10 thoughts on “P41 – Haigh”
What is the significance of a Cluster B designation in bacteriophages?
Cluster B phages are lytic, meaning that they lyse the bacterial cell rather than denature it. In addition, cluster B phages have siphoviridae morphology, which is very similar to cluster A phages. Our result was particularly interesting as most bacteriophage isolated belong to cluster A.
Did you have any unexpected results?
In lab, we weren’t able to isolate our own bacteriophage, so we adopted a phage that had been previously isolated, but not characterized. Our results were not particularly surprising, but we were the only group in our lab section to have isolated a lytic phage as opposed to a lysogenic phage which is pretty cool!
How can this research help with TB? Why is it important that the phage is lytic?
If more research is done on our phage, it is possible that it could be used as an alternative to antibiotics to treat tuberculosis. Lytic phages lyse the bacteria cell, while lysogenic cells just denature the bacteria cell meaning that lytic phages are more effective to use in phage therapy because the cell is destroyed.
If more research is done on this phage, it could be used as an alternative to antibiotics to treat tuberculosis. Since Carrot is lytic, it lyses the bacterial host cell and releases more phage into the environment rather than silencing bacterial function like a lysogenic cell. Lytic phage are more effective in gene therapy.
What characteristics do B-cluster phage possess?
Cluster B phages are lytic, which means that they lyse the cell and release more phage into the environment rather than incorporate their DNA into the bacterial host genome to silence the function of the bacterial cell. Additionally, cluster B phages are siphoviridae and have a long tail with a capsid head.
Excellent presentation Anna!! You were fantastic all throughout the semester and such a thoughtful learner! So glad to see that expressed in this video!