8 thoughts on “P48 – Lee

    1. Phages need to express lytic genes in order to enter the lytic cycle, which results in the death of the host bacteria cell! Phages in the temperate cycle will not be effective for phage therapy since they will not kill the host bacteria cell, until they express lytic genes and enter the lytic cycle.

  1. Hi, Kendall, great job! Does bacteriophage Deloris being lysogenic (versus lytic) change the ways it can be used in therapeutic medicine?

    1. Hi Claire, thank you! In order to be used for therapeutic purposes, Deloris would need to be genetically modified to express lytic genes, since phages in the temperate cycle do not kill the host bacteria cell.

  2. Is there any reason to modify a naturally lysogenic bacteria for therapeutic use instead of using a lytic species?

    1. Good question! Depending on the species of bacteria that needs to be killed, phages with different characteristics will be more or less effective than others. Being able to modify temperate phages for phage therapy purposes rather than only looking at lytic phages, greatly increases the amount of phages that can be searched to find the exact ones that will work for a specific therapy.

    1. Thank you! A temperate phage, as opposed to a lytic phage, is a phage that is capable of reproducing through either the lysogenic or the lytic life cycle. A lytic phage can only enter the lytic cycle. Temperate phages will enter the lysogenic cycle as long as their repressors are stopping them from expressing lytic genes. If the repressor gets degraded, a temperate phage will express lytic genes and enter the lytic lifecycle.

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