Yes! By having a greater understanding of the genes that play a role in repairing DNA damage, more efficient diagnoses and possibly earlier diagnoses can be administered to patients that have access to cancer pre-screening. Additionally, synthetic drugs that can augment gene expression of genes that lack necessary expression for DNA damage or cell cycle regulation may be developed as more DDR genes are identified.
You mentioned in the future directions area that researchers could go further beyond the limitations in this lab, what limitations do you think they could bypass?
Researches may be able to utilize more direct analysis of gene expression such as Western blotting which measures protein accumulation rather than transcription. With this, researchers may bypass any possibility of post-translational repression of gene products.
Tetrahymena thermophila or “pond scum,” as stated in the presentation, are very biochemically manipulative, cheap, accessible, and have high levels of conserved eukaryotic genes, especially with humans; making it a great model organism for recurring research for human applications.
curesymposium.org 
Great presentation! You mentioned that this research has implications for cancer treatment- could you go into greater detail about that? Thanks!
LikeLike
Yes! By having a greater understanding of the genes that play a role in repairing DNA damage, more efficient diagnoses and possibly earlier diagnoses can be administered to patients that have access to cancer pre-screening. Additionally, synthetic drugs that can augment gene expression of genes that lack necessary expression for DNA damage or cell cycle regulation may be developed as more DDR genes are identified.
LikeLike
You mentioned in the future directions area that researchers could go further beyond the limitations in this lab, what limitations do you think they could bypass?
LikeLike
Researches may be able to utilize more direct analysis of gene expression such as Western blotting which measures protein accumulation rather than transcription. With this, researchers may bypass any possibility of post-translational repression of gene products.
LikeLike
Can you explain a it more about the functionality of the twi-8 gene? Does it have any other functions?
LikeLike
The Twi8 gene is an sRNA that participates in meiotic nuclear development and does not participate in the somatic cell DNA damage response mechanism.
LikeLike
What qualities of the model organism lead to you choosing it for this research?
LikeLike
Tetrahymena thermophila or “pond scum,” as stated in the presentation, are very biochemically manipulative, cheap, accessible, and have high levels of conserved eukaryotic genes, especially with humans; making it a great model organism for recurring research for human applications.
LikeLike