The WD40 repeat (found within WD40-containing proteins) has been implicated in a number of cellular processes including cell cycle control and apoptosis, both of which are critical to the onset and progression of cancer. Because of this, it stands to reason that mutations within genes encoding WD40-containing proteins could result in altered/disregulated cellular processes, thereby contributing to the progression of cancer. A thorough study of these proteins (as well as others involved in cancer-related cellular processes) can therefore aid us not only in better understanding the underlying biology of cancer, but can also help with the design of more effective, targeted cancer therapies.
According to an article published in 2001, hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide. These molecules can engage in 2 distinct DNA damage pathways, one of which involves the oxidation of nucleotides, which can result in mutations due to mispaired bases. DNA damage can also be induced via depurination, which involves the loss of a purine base from a DNA molecule.
curesymposium.org 
what causes DNA damage?
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How does the WD-40 protein help research in cancer studies?
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The WD40 repeat (found within WD40-containing proteins) has been implicated in a number of cellular processes including cell cycle control and apoptosis, both of which are critical to the onset and progression of cancer. Because of this, it stands to reason that mutations within genes encoding WD40-containing proteins could result in altered/disregulated cellular processes, thereby contributing to the progression of cancer. A thorough study of these proteins (as well as others involved in cancer-related cellular processes) can therefore aid us not only in better understanding the underlying biology of cancer, but can also help with the design of more effective, targeted cancer therapies.
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According to an article published in 2001, hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide. These molecules can engage in 2 distinct DNA damage pathways, one of which involves the oxidation of nucleotides, which can result in mutations due to mispaired bases. DNA damage can also be induced via depurination, which involves the loss of a purine base from a DNA molecule.
If you are interested, here is the link to the corresponding article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926660/
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