Good presentation! How do you know that this compound is effective in DNA repair more specifically than it just being researched in the past? Just so I can get a general idea of how it “fixes” damaged DNA.
We are currently unsure if this compound is completely effective in DNA repair since we’ve only tested its expression during DNA damage. The only evidence we have so far is its expression peaks during DNA damage.
It could potentially be used for DNA repair in humans, but more testing would need to be done in our model organism first to see if it is truly involved in DNA damage repair.
Hey Bao! Great job with you research. My question concerns the method of repair that RRM2 uses to repair these breaks. It is stated that T. thermohilla repairs double-stranded breaks with high efficacy. Although it is not stated if RRM2 uses homologous-recombination or non-homologous end joining to repair these breaks. Would you say given the high-efficacy in repair that homologous-recombination is the most likely method of repair?
This presentation was very interesting to listen to. When you mention tagging the RRM2, how would you go about doing this? Would you tag it with a fluorescent tag to see its effects, or something else?
Very well organized and interesting presentation with great explanations of future experimentation. I was wondering, how does heightened expression of RRM2 in C6-C8 and C14-C16 conjugation phases of meiosis relate to DNA damage and expression?
When DNA damage was induced in RRM2, the C6-C8 and C14-C16 conjugation phases represent an increase in expression that represent the potential repair of Tetrahymera.
curesymposium.org 
Good presentation! How do you know that this compound is effective in DNA repair more specifically than it just being researched in the past? Just so I can get a general idea of how it “fixes” damaged DNA.
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We are currently unsure if this compound is completely effective in DNA repair since we’ve only tested its expression during DNA damage. The only evidence we have so far is its expression peaks during DNA damage.
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Is it possible to use the RRM2 gene for DNA repair in humans?
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It could potentially be used for DNA repair in humans, but more testing would need to be done in our model organism first to see if it is truly involved in DNA damage repair.
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Hey Bao! Great job with you research. My question concerns the method of repair that RRM2 uses to repair these breaks. It is stated that T. thermohilla repairs double-stranded breaks with high efficacy. Although it is not stated if RRM2 uses homologous-recombination or non-homologous end joining to repair these breaks. Would you say given the high-efficacy in repair that homologous-recombination is the most likely method of repair?
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I’m not sure if RRM2 uses homologous-recombination or non-homologous end joining despite the high-efficacy.
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This presentation was very interesting to listen to. When you mention tagging the RRM2, how would you go about doing this? Would you tag it with a fluorescent tag to see its effects, or something else?
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We would use a fluorescent tag to see its location and effects on other proteins during DNA damage.
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Very well organized and interesting presentation with great explanations of future experimentation. I was wondering, how does heightened expression of RRM2 in C6-C8 and C14-C16 conjugation phases of meiosis relate to DNA damage and expression?
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When DNA damage was induced in RRM2, the C6-C8 and C14-C16 conjugation phases represent an increase in expression that represent the potential repair of Tetrahymera.
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