Sure thing, a max dose experiment is aimed to test the highest possible dose of the compound that can be administered to humans which in this case was 10ug/mL. This tests whether or not the compound is a hit, if it is a hit then dilutions can be done to see the minimal effective dose, if it is not a hit then the research can progress in other directions without wasting time and resources on dilutions and other tests.
I would consider this valuable information! I think it needs further testing before it is completely ruled out but I believe this research gives a good idea as to its efficacy.
There is a lot of research showing that it is has antimicrobial properties as well as research showing that it has minimal toxic effects to cells. These two properties in conjunction make it desirable as an antibiotic should it really have these antimicrobial properties.
Could you please explain to me what a max dose experiment is and what it tests for?
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Sure thing, a max dose experiment is aimed to test the highest possible dose of the compound that can be administered to humans which in this case was 10ug/mL. This tests whether or not the compound is a hit, if it is a hit then dilutions can be done to see the minimal effective dose, if it is not a hit then the research can progress in other directions without wasting time and resources on dilutions and other tests.
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Great job Kieran! Even though Mastoparan-X proved to not be a HIT, would you still consider these results valuable information?
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I would consider this valuable information! I think it needs further testing before it is completely ruled out but I believe this research gives a good idea as to its efficacy.
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What made mastoparan-X a good candidate to test to fight salmonella in the first place?
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What made mastoparan_X a good candidate to test for this research?
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There is a lot of research showing that it is has antimicrobial properties as well as research showing that it has minimal toxic effects to cells. These two properties in conjunction make it desirable as an antibiotic should it really have these antimicrobial properties.
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To piggyback on the previous max dose Q&A, how did you come up with the max dose that you used?
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This dose was given to us, I am not quite sure how it was established.
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