There are a ton of different components of green tea. Just within the Catechins group we have 6 Gallolated compounds that have various degrees of hits for a potential antibiotic in other model organisms.
This is one where a multi-compound screen would be key to do once you identify all the compounds in green tea and then look into purification for easy pharmacological distribution and manufacturing.
Hi Cristian! Great presentation and research. I was wondering why it would only hinder it and not completely kill it off. Is it due to strength of the bacteria or something else?
Great question! There are many mechanisms behind how antibiotics can target a bacterias ability to either hinder growth or kill it.
We are able to phenotypically see that, though that bactericidal/bacteriostatic experiment, that just like ampicillin it just inhibits growth (this gives the body time to catch up and deal with the infection).
There are many ways to determine what component ECGC may be targeting that can give rise to what we see phenotypically. Pharmacokinetics could also give us a glimpse into this solution.
Unfortunately we ran out of time so we just saw a very small sliver of the pie – but that would be a great future direction as well
That is a great question! The mechanism behind how different drugs work could be important clinically. If you already have a damaged immune system then you would want to refrain from using a bacteriostatic antibiotic since those just cause the bacteria to not keep growing and let your own immune system handle it. In cases with immune deficiency a bactericidal antibiotic is preferred just because it would kill the bacteria off and the cleanup for it can be done later by your immune system when it is stronger.
According to a paper from Bio Med Central “The major active ingredients in green tea are the catechins”. One of the Catechins being our compound of interest.
This paper specifically states that these compounds “were highly effective in inhibiting infection of live SARS-CoV-2 and human coronavirus” Which is a really cool finding!
To try and answer your second question – it is hard to say. Just because something is an active ingredient in tea doesn’t mean that is it processed by the body though the GI tract or that it behaves the same way in a certain concentration in the body or it as a standalone compound. This is the basis of why clinical trails are so important to be done!
curesymposium.org 
How has your research broadened your understanding of the way green tea works according to the outcome of your research?
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Hello Bergman!
There are a ton of different components of green tea. Just within the Catechins group we have 6 Gallolated compounds that have various degrees of hits for a potential antibiotic in other model organisms.
This is one where a multi-compound screen would be key to do once you identify all the compounds in green tea and then look into purification for easy pharmacological distribution and manufacturing.
Great Question!
Cristian Joya
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Hi Cristian! Great presentation and research. I was wondering why it would only hinder it and not completely kill it off. Is it due to strength of the bacteria or something else?
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Hello Brennyn!
Great question! There are many mechanisms behind how antibiotics can target a bacterias ability to either hinder growth or kill it.
We are able to phenotypically see that, though that bactericidal/bacteriostatic experiment, that just like ampicillin it just inhibits growth (this gives the body time to catch up and deal with the infection).
There are many ways to determine what component ECGC may be targeting that can give rise to what we see phenotypically. Pharmacokinetics could also give us a glimpse into this solution.
Unfortunately we ran out of time so we just saw a very small sliver of the pie – but that would be a great future direction as well
Cristian Joya
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Why is it being bactericidal or bacteriostatic important? What does bacteria being allowed to grow means when it comes to your results?
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Hello Julia!
That is a great question! The mechanism behind how different drugs work could be important clinically. If you already have a damaged immune system then you would want to refrain from using a bacteriostatic antibiotic since those just cause the bacteria to not keep growing and let your own immune system handle it. In cases with immune deficiency a bactericidal antibiotic is preferred just because it would kill the bacteria off and the cleanup for it can be done later by your immune system when it is stronger.
Hope that answers your question!
Cristian Joya
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So is the green tea component you tested active in green tea? Would bacteria in people who drink a lot of green tea be more resistant?
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Hello Mir!
According to a paper from Bio Med Central “The major active ingredients in green tea are the catechins”. One of the Catechins being our compound of interest.
This paper specifically states that these compounds “were highly effective in inhibiting infection of live SARS-CoV-2 and human coronavirus” Which is a really cool finding!
It is a cool story to check out if you have time: https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-021-00680-8
To try and answer your second question – it is hard to say. Just because something is an active ingredient in tea doesn’t mean that is it processed by the body though the GI tract or that it behaves the same way in a certain concentration in the body or it as a standalone compound. This is the basis of why clinical trails are so important to be done!
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Why do you believe a lab grade concentration would be better to study?
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is it always active on green tea? and is it present on other plant teas?
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is it alway active on green tea? can you find it in other plant teas?
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