Great question. Since this information was from another source, I am not completely familiar with the mechanisms by which the membrane was compromised. My best guess would be that 4HBITC ruptures the membrane in some way, and without the semipermeable barrier the cell integrity as a whole is endangered.
Yes. If a drug developed from this compound successfully kills Salmonella Typhi, it is guaranteed to be successful against Salmonella Typhimurium, since they share the same structure. It may also kill similarly gram-negative bacterium since they share structural similarities, but testing would be required to verify this.
We want to repeat the experiments to make sure the results were not dependent on human error or other uncontrolled variables, especially our second dilution series that had mixed results.
In your graph, what does the red line above the bars represent?
LikeLike
The red lines are error bars, they represent the variability in the data we received.
LikeLike
How does 4HBITC compromise bacterial membranes?
LikeLike
Great question. Since this information was from another source, I am not completely familiar with the mechanisms by which the membrane was compromised. My best guess would be that 4HBITC ruptures the membrane in some way, and without the semipermeable barrier the cell integrity as a whole is endangered.
LikeLike
If you can kill salmonella typhi is there any other bacteria this process could kill in the future
LikeLike
Yes. If a drug developed from this compound successfully kills Salmonella Typhi, it is guaranteed to be successful against Salmonella Typhimurium, since they share the same structure. It may also kill similarly gram-negative bacterium since they share structural similarities, but testing would be required to verify this.
LikeLike
Why do you want to repeat the experiments in the future?
LikeLike
We want to repeat the experiments to make sure the results were not dependent on human error or other uncontrolled variables, especially our second dilution series that had mixed results.
LikeLike