Thanks for asking Nadine. Our interesting results suggested that due to the increased cell survival rate of irradiated flys exposed to MET, the compound may have implications in reducing the harmful effect of radiation in cells. Obviously no “Hits” were found in our studies but further experimentation with MET, in a radiation protector context, could reveal a new application for the compound. Obviously this is speculation but it’s interesting nevertheless.
It was stated that other combinations of drugs for the MET solution could be more effective therapeutically; do you have any guesses for drugs that might work better or why?
Hey Kendall, great question! Previous studies suggest that vemurafenib and trametinib (current melanoma drugs) can have increased effect when combined with MET. This combination has been shown to increase the cytotoxicity and reduce the possibility for cell resistance during treatment.
Good question Justin. We personally did not have a hand in the irradiation of our flys (Thank God). The process, however, is generally safe as radiation only occurs when the machine is on and the radiation is highly focused.
Any ideas on how to identify a drug that would work with your compound as a chemotherapeutic? Also, how was this idea determined? Is there literature already published on the topic?
Thanks for asking! There is a plethora of literature that suggest that multiple drugs have increased function when paired with MET. One example I can share is in melanoma treatments, where MET has shown to increase cytotoxicity of vemurafenib and trametinib. We figured that if it makes other drugs better maybe it can work alone given the right dose.
curesymposium.org 
Why can MET potentially be radiation protector, even without it getting any hits?
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Thanks for asking Nadine. Our interesting results suggested that due to the increased cell survival rate of irradiated flys exposed to MET, the compound may have implications in reducing the harmful effect of radiation in cells. Obviously no “Hits” were found in our studies but further experimentation with MET, in a radiation protector context, could reveal a new application for the compound. Obviously this is speculation but it’s interesting nevertheless.
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It was stated that other combinations of drugs for the MET solution could be more effective therapeutically; do you have any guesses for drugs that might work better or why?
LikeLike
Hey Kendall, great question! Previous studies suggest that vemurafenib and trametinib (current melanoma drugs) can have increased effect when combined with MET. This combination has been shown to increase the cytotoxicity and reduce the possibility for cell resistance during treatment.
LikeLike
How did you expose the flies to radiation? What safety precautions (if any) did you have to take when doing this process?
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Good question Justin. We personally did not have a hand in the irradiation of our flys (Thank God). The process, however, is generally safe as radiation only occurs when the machine is on and the radiation is highly focused.
LikeLike
Any ideas on how to identify a drug that would work with your compound as a chemotherapeutic? Also, how was this idea determined? Is there literature already published on the topic?
LikeLike
Thanks for asking! There is a plethora of literature that suggest that multiple drugs have increased function when paired with MET. One example I can share is in melanoma treatments, where MET has shown to increase cytotoxicity of vemurafenib and trametinib. We figured that if it makes other drugs better maybe it can work alone given the right dose.
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