If the Siphoviridae demonstrates possibility of success with biotechnology, can you discuss how they would interact with or increase activity of an immune cell like a macrophage, and would the phage protein’s interaction with a macrophage initiate a more efficient recovery from a virus or bacteria caused illness?
Some phage therapies that have been tested in human hosts have resulted in a quicker death due to the fact that the phage treatment aggravated the immune system of the person and that made the infection much worse and put more stress on the body. So, in some cases, phage (not necessarily just siphoviridae, but other morphologies as well) increased the activity of immune cells and that was negative for the host. However, if the phage can be introduced to the body without aggravating the immune system (whether that is putting the patient on an immunosuppressant or removing some type of signaling molecule from the phage so it will not be recognized by the immune system) the phage do not increase the activity of the immune cells, and prevent potential stress on the body, and they still go on to the remainder of the body to eliminate the bacterial infection.
I’m not sure that lytic or lysogenic life-cycles are more successful – I would assume that a phage capable of choosing its lifecycle (a temperate phage) would have a slight advantage over a lytic phage, which can only pursue a lytic life cycle. Temperate phage can choose a lysogenic life cycle, and can then integrate their genome and stay in the host cell for as long as they need, or until the cell is no longer favorable, and that can be a long time. The lysogenic cycle also allows the phage to reproduce without necessarily killing the host (or at the very least, killing the host as fast as a lytic phage), which may be more beneficial than a lytic phage and lytic life cycle.
Our phages may also prove useful in areas such as agriculture, as in preventing crops and other food from being infected by bacteria, (the lytic would work well for this, as it would immediately lyse bacteria cells and therefore kill the bacteria) and phage therapy in infected patients (again, the lytic phage would probably work best because it would most quickly kill harmful bacteria).
Yes, our phages (especially the temperate with the lysogenic life-cycle, which incorporates its genome into the bacteria) could be used for other variations of COVID-19 and other vaccines. They are great forms of transportation for any vaccine, since they infiltrate cells so well and effectively, insert their DNA really well, and the lysogenic phage also would still result in enhanced immune response against other viruses due to incorporating its genome into host cells.
curesymposium.org 
If the Siphoviridae demonstrates possibility of success with biotechnology, can you discuss how they would interact with or increase activity of an immune cell like a macrophage, and would the phage protein’s interaction with a macrophage initiate a more efficient recovery from a virus or bacteria caused illness?
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Some phage therapies that have been tested in human hosts have resulted in a quicker death due to the fact that the phage treatment aggravated the immune system of the person and that made the infection much worse and put more stress on the body. So, in some cases, phage (not necessarily just siphoviridae, but other morphologies as well) increased the activity of immune cells and that was negative for the host. However, if the phage can be introduced to the body without aggravating the immune system (whether that is putting the patient on an immunosuppressant or removing some type of signaling molecule from the phage so it will not be recognized by the immune system) the phage do not increase the activity of the immune cells, and prevent potential stress on the body, and they still go on to the remainder of the body to eliminate the bacterial infection.
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Do you know if lytic or lysogenic life cycles are more successful evolutionarily? Does one have an advantage for phages over the other?
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I’m not sure that lytic or lysogenic life-cycles are more successful – I would assume that a phage capable of choosing its lifecycle (a temperate phage) would have a slight advantage over a lytic phage, which can only pursue a lytic life cycle. Temperate phage can choose a lysogenic life cycle, and can then integrate their genome and stay in the host cell for as long as they need, or until the cell is no longer favorable, and that can be a long time. The lysogenic cycle also allows the phage to reproduce without necessarily killing the host (or at the very least, killing the host as fast as a lytic phage), which may be more beneficial than a lytic phage and lytic life cycle.
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What other roles could your phages have besides being used in vaccines?
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Our phages may also prove useful in areas such as agriculture, as in preventing crops and other food from being infected by bacteria, (the lytic would work well for this, as it would immediately lyse bacteria cells and therefore kill the bacteria) and phage therapy in infected patients (again, the lytic phage would probably work best because it would most quickly kill harmful bacteria).
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Could your phages still be useful against other variations of COVID-19 or other retro-viruses?
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Yes, our phages (especially the temperate with the lysogenic life-cycle, which incorporates its genome into the bacteria) could be used for other variations of COVID-19 and other vaccines. They are great forms of transportation for any vaccine, since they infiltrate cells so well and effectively, insert their DNA really well, and the lysogenic phage also would still result in enhanced immune response against other viruses due to incorporating its genome into host cells.
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