The lytic phages are preferred for phage therapy over temperate because they lyse the bacterial cell immediately after infection. So you can genetically modify a temperate phage and take out the genome that addresses the lysogenic function and replace it with the genome that induces the lytic function. That would turn the phage into a lytic phage, making it much better for use in phage therapy.
great presentation!
How do the results of having a temperate phage or being a part of the subcluster A1 or having siphoviredae morphology relate to eliminating antibiotic resistance? In other words, how does your data relate to eliminating antibiotic resistance?
As for having a temperate phage, it relates to eliminating antibiotic resistant bacteria because it can be used for phage therapy after the lysogenic genome is replaced with the lytic genome. That would turn the phage into a lytic phage which are preferred for phage therapy. For the big picture, our phage goes into a phage database where doctors can use it and administer it to patients that are about to die and have no other option to see if it works and kills the antibiotic resistant bacterial cells.
curesymposium.org 
How does a temperate phage transition into a lytic phage?
LikeLike
The lytic phages are preferred for phage therapy over temperate because they lyse the bacterial cell immediately after infection. So you can genetically modify a temperate phage and take out the genome that addresses the lysogenic function and replace it with the genome that induces the lytic function. That would turn the phage into a lytic phage, making it much better for use in phage therapy.
LikeLike
great presentation!
How do the results of having a temperate phage or being a part of the subcluster A1 or having siphoviredae morphology relate to eliminating antibiotic resistance? In other words, how does your data relate to eliminating antibiotic resistance?
LikeLike
As for having a temperate phage, it relates to eliminating antibiotic resistant bacteria because it can be used for phage therapy after the lysogenic genome is replaced with the lytic genome. That would turn the phage into a lytic phage which are preferred for phage therapy. For the big picture, our phage goes into a phage database where doctors can use it and administer it to patients that are about to die and have no other option to see if it works and kills the antibiotic resistant bacterial cells.
LikeLike