Phage therapy is a medical treatment that can be used for antibiotic resistant pathogens. In phage therapy, viruses are used to treat a pathogen because phage can insert their genetic material into the bacteria replicate then kill the bacteria, thus completely eradicating the pathogen.
When you preform your restricted-digest (I think this is what was said during your methods) and view the cuts of the DNA, why does it matter that your phage cluster is similar to other clusters?
Categorizing phage by clusters is a great organizational tool for phage therapy. Phages of similar clusters have similar genomes and thus similar functions. So if phages from cluster A are shown to cause lysis in a certain bacteria other ones from that same cluster could be useful for phage therapy.
Determining phage clusters is an important organization tool. Phages of similar genomes are placed into similar clusters and phages with similar genomes are also likely to have similar functions. Phages of the same cluster likely have similar traits and morphology. Having these clusters can help researchers easily choose phages in a cluster with certain characteristics that might be beneficial to phage therapy.
Phage therapy is possible because of the unique characteristics that phage use by infecting the host cell using the host cell to recreate phage parts and then those newly composed phage parts bursting out of the host cell causing it to die. Theoretically phages can infect any living thing it could be possible to use this same mechanism on other diseases such as fungal infections. However phage are very specific in the organism they infect and bacteriophage only infect bacteria, using other types of phages could be dangerous because using other phages could cause the virus to infect the patient and not the intended disease.
Along with finding the areas of the genome that cause Zadelle to be temperate to change that to be more efficient for phage therapy. It could be interesting to see if there are areas in the genome that make Zadelle able to infect bacteria efficiently or if Zadelle could possible infect multiple types of pathogens. All allowing for more insights in how Zadelle could be used for phage therapy.
As of now temperate phages are not suitable for phage therapy because it goes through the lysogenic cycle. Hopefully by sequencing the genome we can find the sections of the genome that cause the phage to be temperate and remove those so it only has a lytic cycle and not lysogenic cycle. This would make the phage more suitable for phage therapy.
The continued use of antibiotics is what causes antibiotic resistance to develop within bacteria. As of now the only means to keep antibiotic resistance down is using a wide variety of different types of antibiotics to try and prevent bacteria from becoming resistant. This is only a temperate solution, and thus why phage therapy and other possible solutions are important alternatives to look into.
curesymposium.org 
what is phage therapy?
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Phage therapy is a medical treatment that can be used for antibiotic resistant pathogens. In phage therapy, viruses are used to treat a pathogen because phage can insert their genetic material into the bacteria replicate then kill the bacteria, thus completely eradicating the pathogen.
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When you preform your restricted-digest (I think this is what was said during your methods) and view the cuts of the DNA, why does it matter that your phage cluster is similar to other clusters?
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Categorizing phage by clusters is a great organizational tool for phage therapy. Phages of similar clusters have similar genomes and thus similar functions. So if phages from cluster A are shown to cause lysis in a certain bacteria other ones from that same cluster could be useful for phage therapy.
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Determining phage clusters is an important organization tool. Phages of similar genomes are placed into similar clusters and phages with similar genomes are also likely to have similar functions. Phages of the same cluster likely have similar traits and morphology. Having these clusters can help researchers easily choose phages in a cluster with certain characteristics that might be beneficial to phage therapy.
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Is phage therapy only used for bacterial infections or could we see other health problems use phage therapy?
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Phage therapy is possible because of the unique characteristics that phage use by infecting the host cell using the host cell to recreate phage parts and then those newly composed phage parts bursting out of the host cell causing it to die. Theoretically phages can infect any living thing it could be possible to use this same mechanism on other diseases such as fungal infections. However phage are very specific in the organism they infect and bacteriophage only infect bacteria, using other types of phages could be dangerous because using other phages could cause the virus to infect the patient and not the intended disease.
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What features present in the genome sequencing would help determine Zadelles possible uses for phage therapy?
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Along with finding the areas of the genome that cause Zadelle to be temperate to change that to be more efficient for phage therapy. It could be interesting to see if there are areas in the genome that make Zadelle able to infect bacteria efficiently or if Zadelle could possible infect multiple types of pathogens. All allowing for more insights in how Zadelle could be used for phage therapy.
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By sequencing the genome how will you be able to tell what it will applications it will be useful for?
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As of now temperate phages are not suitable for phage therapy because it goes through the lysogenic cycle. Hopefully by sequencing the genome we can find the sections of the genome that cause the phage to be temperate and remove those so it only has a lytic cycle and not lysogenic cycle. This would make the phage more suitable for phage therapy.
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Do you know of any other alternate solutions to phage therapy to decreasing antibiotic resistance?
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The continued use of antibiotics is what causes antibiotic resistance to develop within bacteria. As of now the only means to keep antibiotic resistance down is using a wide variety of different types of antibiotics to try and prevent bacteria from becoming resistant. This is only a temperate solution, and thus why phage therapy and other possible solutions are important alternatives to look into.
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