6 thoughts on “D15 – Gattey

  1. After determining that Brinzolamide wasn’t effective as an antibiotic to this bacteria sample, did you test against other samples of the same bacteria to see if a different result occurred?

    1. Unfortunately, the only bacteria we could test was the Salmonella Typhimurium sample because we were concerned specifically about the implications on this bacteria specifically. Ideally, we would be able to test a range of differing bacteria, but there are lab safety issues to think about as well as cost etc. Hopefully, this helps!

  2. Hi! You poster was very well explained! During your research after you found that Brinzolamide did not work, were you able to find other compounds that could possibly inhibit the carbonicanhydrase found in Salmonella Typhimurium?

    1. Our group specifically did not. As a whole group we tested over 2000 compounds and I believe we had about 15 “hits” meaning they were greater than 2 SD away from the DMSO negative control mean. These compounds were tested by other classmates as well as hopefully more in the future. Thank you for the comments!

  3. Do you think that there was anything you could have done differently in your experiments to yield a different result?

    1. There are a lot of variables that we could have changed. We chose to manipulate the concentration of our chosen compound, but a different compound could have yielded a different result. I would have liked to explore other carbonic anhydrase inhibitors that act on different portions of the metabolic processes of these bacteria.

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