6 thoughts on “D15A – Renner

  1. How do you think the antioxidant properties and phytochemicals in GSE contributed to its efficacy in terms of disrupting rapid division?

    1. Honestly, I am not sure how Grape Seed Extract (GSE) and its antioxidant properties disrupt rapid cellular division. I think it has something to do with reactivating the tumor suppressor gene. The tumor suppressor gene inhibits cell division and cell survival, this means if GSE reactivates this gene, then those cancer cells will be destroyed as the tumor suppressor gene does its job. I am not sure if this is possible in anyway, but I do believe it has some sort of function in reactivating apoptosis in the cells which would explain its antioxidant properties and how GSE disrupts rapid cellular division. If you’d like, you can email your question to me (dyre5942@colorado.edu) and I can get back to you with a more confident answer.

    1. Our concentrations were actually given to us. We were told to dilute our stock concentration of 100 mg/mL in a ratio of 1:2. We did that to get our concentrations of 50 mg/mL, we then diluted this new concentration again to get 25 mg/mL, and once more for 12.5 mg/mL. Long story short, we did not really decide on them but the point is to lower the concentration to find the most effective dosage that provides a percent survival that is considered a hit (two standard deviations above or below the percent survival of the negative control, DMSO).

    1. Just the fact that when Grape Seed Extract (GSE) was added to the food, the percent survival of all of our doses for GSE was two standard deviations below the mean survival of the negative control, DMSO. This represents that it can be a hit and a potential chemotherapy because its percent survival is so low. If the percent survival was two standard deviations above the mean survival of the negative control, it would also be a hit, but that just represents a radiation protector instead of a potential chemotherapy.

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