While Melittin may possess antibiotic characteristics and has been recognized for its antimicrobial properties, it is not a validated antibiotic. Additional tests and studies would need to be preformed in order to learn about Melittins mechanisms and if it could be classified as an antibiotic that salmonella or any bacteria could become resistant to through random mutations.
An experimental set up to address Melittin’s limitations would look like preforming additional dosage series to see its most effective dose while still having a therapeutic effect, additional timing series to see if it is a bacteriostatic or bactericidal drug, and if it could be classified as an antibiotic. Really in addressing Melittin’s limitations we are looking for what the compound can and can’t do effectively.
The goal of identifying Melittin’s limitations is to see at what dosage it is most effective while still having a therapeutic effect, test if it could be classified as an antibiotic, or preforming further tests to see if it is bacteriostatic or bactericidal. Some ways you could specifically identify Melitten’s limitations is to preform additional dosage series (blind and/or double blind to limit potential bias), timing series, and test the compounds effectiveness to work as a possible antibiotic.
Gram positive bacteria have a thick peptidoglycan layer, making them harder to penetrate than gram negative bacteria which only has a thin layer. The thick peptidoglycan layer is so strong due to the cross-linking of amino acids, providing extra strength.
Can Salmonella develop antibiotic resistance against melittin, not longer able to inhibit its growth?
While Melittin may possess antibiotic characteristics and has been recognized for its antimicrobial properties, it is not a validated antibiotic. Additional tests and studies would need to be preformed in order to learn about Melittins mechanisms and if it could be classified as an antibiotic that salmonella or any bacteria could become resistant to through random mutations.
What would an experimental set up be that addresses Melittin’s limitations?
An experimental set up to address Melittin’s limitations would look like preforming additional dosage series to see its most effective dose while still having a therapeutic effect, additional timing series to see if it is a bacteriostatic or bactericidal drug, and if it could be classified as an antibiotic. Really in addressing Melittin’s limitations we are looking for what the compound can and can’t do effectively.
How could you specifically identify Melitten’s limitations?
The goal of identifying Melittin’s limitations is to see at what dosage it is most effective while still having a therapeutic effect, test if it could be classified as an antibiotic, or preforming further tests to see if it is bacteriostatic or bactericidal. Some ways you could specifically identify Melitten’s limitations is to preform additional dosage series (blind and/or double blind to limit potential bias), timing series, and test the compounds effectiveness to work as a possible antibiotic.
What is the protective outer coat of the Salmonella Typh. made of that makes it so hard to penetrate?
Gram positive bacteria have a thick peptidoglycan layer, making them harder to penetrate than gram negative bacteria which only has a thin layer. The thick peptidoglycan layer is so strong due to the cross-linking of amino acids, providing extra strength.