8 thoughts on “D62 – Agyepong

  1. Hi! This presentation was amazing. You mentioned that your conflicting results might have been a result of concentration differences between your solutions. What do you think would be the ideal concentration for your solutions to have maximally antibiotic properties?

    1. Thank you for the question! We initially intended for the concentration of the solution to 10µM due to equipment limitation, but as for what concentration for maximally antibiotic properties that’s a bit more difficult to tell. Chlorogenic Acid and quercetin are found in a lot of fruits and things like coffee beans, so believe there’s quite a range for an ideal concentration. I know for quercetin, concentration more than 200 μM have more potential direct therapeutic properties as studies have shown.

  2. This was a really engaging presentation! What other combinations of acids or chemical compounds do you hypothesize would also help fight against antibiotic resistant bacteria?

    1. Thank you for the great question! Myricetin is one possible compound that could help fight against antibiotic resistant bacteria. It wouldn’t be an antibiotic since it does nothing to bacterial growth, but research has shown that it does inhibit the virulence factors of some bacteria. Therefore Myricetin can be used with a known antibiotic and take out some of the virulence factors, increasing the chances that the antibiotic would be effective if it was not before. Myricetin was also found in many of the ingredients in Enterica.

  3. This presentation was the bomb! I loved how clearly you explained everything and it all flowed super nicely. I wonder if it is something else in Interica that has the antibiotic properties? I also honk it is so interesting because I feel that a lot of people are switching from traditional medicine to a more holistic approach involving more naturopathic medicines to keep them health so I think this research is really current and I love that.

    1. Thank you so much! We found a vast multitude of similar compounds in all/ most of the ingredients of Enterica, so it’s very possible that something else may contain antibiotic properties and the compound we tested just help support it. Also many of the other compounds also have shown promising results in other bacteria, so ultimately part of it also came down to what we could get our hands on in this period of time. But lots of potential in the other compounds of enterica! And yes, looking at the traditional route is great!

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