So strontium carbonate nanoparticles seem to not cause toxicity to cells, initiating apoptosis, killing the cell, and inducing apoptosis. Strontium carbonate nanoparticles are used more for carrying other chemotherapeutics because of their high encapsulation efficiency since they themselves aren’t toxic to cells.
What was the reason that the flies that were treated with the maximum does of strontium carbonate nanoparticles and radiation has a lower survival rate?
With the combination of radiation as well as a chemotherapy treatment, the cells are able to receive two kinds of treatment that are able to target different parts of the cell. Without both treatments being administered to that fly, the cells aren’t receiving treatments that one form of treatment can’t do. So when both treatments are administered the flies are going to have a lower survival rate.
Thank you! For this experiment, we were testing the nanoparticles on their own as a form of chemotherapy treatment. What past studies have found is that the nanoparticles are great at encapsulating and delivering hydrophobic chemotherapy drugs
Thank you! For this experiment we tested the nanoparticles themselves as the chemotherapy treatment. The nanoparticles are used/able to encapsulate hydrophobic chemotherapeutic drugs!
Are there any possible long term future experiments that would allow you to test this research on cancer cells (not necessarily in a human, maybe in like a lab rat or something)? Good job! 🙂
Thank you! Yes there are! Similar to this lab experiment, we could replicate this experiment on tumor cell lines, lab rats, or flies with or without mutations that are similar to ones that are in cancerous cells, for example a p53 mutation which is a gene that when mutated isn’t able to slow the rapidly dividing cells that are a result of cancer.
Do you have any idea about why your results didn’t align with the hypothesis?
So strontium carbonate nanoparticles seem to not cause toxicity to cells, initiating apoptosis, killing the cell, and inducing apoptosis. Strontium carbonate nanoparticles are used more for carrying other chemotherapeutics because of their high encapsulation efficiency since they themselves aren’t toxic to cells.
What was the reason that the flies that were treated with the maximum does of strontium carbonate nanoparticles and radiation has a lower survival rate?
With the combination of radiation as well as a chemotherapy treatment, the cells are able to receive two kinds of treatment that are able to target different parts of the cell. Without both treatments being administered to that fly, the cells aren’t receiving treatments that one form of treatment can’t do. So when both treatments are administered the flies are going to have a lower survival rate.
Nice job! What were the nanoparticles supposed to encapsulate?
Thank you! For this experiment, we were testing the nanoparticles on their own as a form of chemotherapy treatment. What past studies have found is that the nanoparticles are great at encapsulating and delivering hydrophobic chemotherapy drugs
Thank you! For this experiment we tested the nanoparticles themselves as the chemotherapy treatment. The nanoparticles are used/able to encapsulate hydrophobic chemotherapeutic drugs!
Are there any possible long term future experiments that would allow you to test this research on cancer cells (not necessarily in a human, maybe in like a lab rat or something)? Good job! 🙂
Thank you! Yes there are! Similar to this lab experiment, we could replicate this experiment on tumor cell lines, lab rats, or flies with or without mutations that are similar to ones that are in cancerous cells, for example a p53 mutation which is a gene that when mutated isn’t able to slow the rapidly dividing cells that are a result of cancer.