This idea is very possible and should be considered if the therapeutic index were to come back with a very low TI. As there is academic literature suggesting that silver nanoparticles work as an antibiotic by damaging the bacteria’s cell wall, another possibility is that at lower concentrations, the number of silver nanoparticles are not enough to penetrate the bacteria.
If the results were to come back indicating a poison, then it would be safe to say that silver nanoparticles should not be used as an antibiotic because it will harm the cells in our body as much as the bacteria cells.
Silver nanoparticles act at an antibiotic by damaging the cell wall of the bacteria, but if the silver nanoparticles were found to have a low therapeutic index due to ED50 and TD50 having similar values (indicating a large toxicity), then that would suggest that the silver nanoparticles would also damage the cell wall of cells in our body which would actually not be considered effective to treat infections.
Do you think the toxicity of silver nanoparticles has an effect on the reason the nanoparticles become less effective as the concentration decreased?
This idea is very possible and should be considered if the therapeutic index were to come back with a very low TI. As there is academic literature suggesting that silver nanoparticles work as an antibiotic by damaging the bacteria’s cell wall, another possibility is that at lower concentrations, the number of silver nanoparticles are not enough to penetrate the bacteria.
If the future direction of using dilutions between 10mg/mL and 5mg/mL did result in a poison being created, how would that change your findings?
If the results were to come back indicating a poison, then it would be safe to say that silver nanoparticles should not be used as an antibiotic because it will harm the cells in our body as much as the bacteria cells.
How is the biological process that makes of nanoparticles toxic and make them effective to treat a infection?
Silver nanoparticles act at an antibiotic by damaging the cell wall of the bacteria, but if the silver nanoparticles were found to have a low therapeutic index due to ED50 and TD50 having similar values (indicating a large toxicity), then that would suggest that the silver nanoparticles would also damage the cell wall of cells in our body which would actually not be considered effective to treat infections.