10 thoughts on “D93 – Verssen

  1. How does the Procyanidin B1 actually work in cancer cell and chemotherapy drug interactions?

    1. Procyanidin B1 interacts with a cancer cell via an inhibition of Kv10.1, a voltage-gated potassium ion channel which is over expressed in 70% of human tumors. Given the overexpression, the Kv10.1 have been shown to play a role in oncogenesis and tumor growth and progression. Procyanidin B1 binds to a binding pocket on the channel causing its direct inhibition, and therefore exhibits anti-proliferative properties in cancer cells, specifically liver cancer where Kv10.1 is especially prominent.

      All information from this response was found in the following study if you’re interested in more information:

      W. Na, B. Ma, S. Shi, Y. Chen, H. Zhang, Y. Zhan, H. An, Procyanidin B1, a novel and specific inhibitor of Kv10.1 channel, suppresses the evolution of hepatoma, Biochemical Pharmacology (2020), doi: https://doi.org/10.1016/j.bcp.2020.114089

    2. Procyanidin B1 interacts with a cancer cell via an inhibition of Kv10.1, a voltage-gated potassium ion channel which is over expressed in 70% of human tumors. Given the overexpression, the Kv10.1 have been shown to play a role in oncogenesis and tumor growth and progression. Procyanidin B1 binds to a binding pocket on the channel causing its direct inhibition, and therefore exhibits anti-proliferative properties in cancer cells, specifically liver cancer where Kv10.1 is especially prominent.

      All information from this response was found in the following study if you’re interested in more information:

      W. Na, B. Ma, S. Shi, Y. Chen, H. Zhang, Y. Zhan, H. An, Procyanidin B1, a novel and specific inhibitor of Kv10.1 channel, suppresses the evolution of hepatoma, Biochemical Pharmacology (2020), doi: https://doi.org/10.1016/j.bcp.2020.114089

  2. How does the procyanidin B1 function in the interactions with cancer cells and chemotherapy drugs?

  3. If procyandidin B1 had proven to be a potential chemotherapeutic how much more research would it have taken to enter human trials?

    1. If procyanidin B1 had been a potential chemotherapeutic, it would take about another 3-4 years to be used in clinical trials. This research would likely include further animal testing in more complex animals like mice to determine the safety of the drug before administering it to humans.

    1. The benefit of using foods containing procyanidin compounds may be that several types of these compounds exist in the extracts of these foods, which may work in combination with one another to inhibit cancer. It is also possible that there is one specific compound in an extract that is responsible for the observed anti-cancer properties, so if an extract is found that has these properties, the next step may be to find the specific compound in it that is responsible for that mechanism.

  4. Would procyanidin B1 be tested on any other specimen (non-human) before moving to clinical trials? Or with further testing would it move directly to clinical trials?

    1. Procyanidin B1 would likely be used in more complex animals that more closely resemble humans before moving to clinical trials, such as mice. The purpose of testing on more complex animals would be to investigate the safety of the drug before administering it to humans.

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