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10 thoughts on “D9B – Miller”
I love the visuals! Do you think that this work could be applied to more than just cancer treatments?
Yes! Andrographis, the herb that andrographolide is from, is used as a drug in the general public to help treat inflammation, and is also used as an antiviral, and antioxidant as well. It is already approved by the FDA so that is why it can be used right now by the general public.
Hey this was a great presentation. Do you think that there would be a way to test to see if there is an optimal dosage of Andrographolide that could be used?
Yes I think that further research would need to be done to verify and possible identify other hits (other concentrations) for andrographolide. From there I would recommend doing multiple tests of the varying concentration hits both with and without radiation. That way you could identify which concentration has the lowest percent survival and compare that to which concentration works best synergistically with radiation therapy.
Why did you choose Andrographolide?
Andrographolide is created from the herb androgrophis paniculata that is already used in the market because of its anti-inflammatory affects and is also able to initiate apoptosis (cell death so cells don’t go on to form cancerous cells). Being able to initiate apoptosis is very promising in not only being able to prevent cancer cells from forming but killing of the cancer cells/ mass that is present. We were also interested in andrographolide because it is from a herb and thought that choosing to test something natural might be a way to identify a safer potential chemotherapy that cancer patients could be treated with.
How do you think your compound is working on a cellular level?
It is known that at a cellular level andrographolide is able to initiate apoptosis (cell death) which is most likely why we found such promising results from testing this compound. Andrographolide also helps to reduce inflammation by interfering with the proteins that bind to DNA to code for pro-inflammatory proteins, therefore stopping the coding of pro-inflammatory proteins and reducing the amount of inflammation in tumors.
Do you think your therapy would be more effective at high or low concentrations? Great presentation.
More testing would be needed because we found the possibility that andrographolide would present in a U shaped dosage curve, meaning that at high and low concentrations there would be a high survival rate (which we don’t want because we want to kill the tumor models and want a low percent survival). If it is true that this compound would present in a U shaped dosage curve than the most effective concentration would be somewhere in the middle of the highest and lowest dosage concentrations.