10 thoughts on “P15 – Peden

  1. I don’t know if I missed it, but did you name the phage? Are certain clusters more effective at killing bacteria?

    1. So, we did name our original phage Tobycat (the non-contaminant phage that we wanted to isolate), but we didn’t end up naming the contaminant since so many people ended up with the same contaminant phage turning up in their samples.

      With the clusters in relation to killing bacteria, no one cluster has the ability to kill all bacteria. Rather, different cluster phages are suited to kill certain types of bacterial species. Phages have something called a “host range,” which refers to the types of bacteria that they are able to kill. This is because bacteria have exterior proteins that certain phages are able to be compatible with in order to effectively infect and kill the bacteria.

  2. Nice presentation Emily! I was wondering what other uses your phage has since you mentioned it is a contaminant and not used in therapy? Did your results give you any clues as to what other fields of research it can be used for ?

    1. Thank you!! Since our phage isn’t able to be archived for phage therapy, the only aspect of research that it may be able to be used in would simply be observing the morphology of O-cluster phages. There may be specific uses for O-cluster phages, but that would require quite a bit more in-depth research. Since a lot of our results were inconclusive, we would likely have to re-do many of the experiments to figure out the fields of research it can be utilized in.

  3. I want to say thank you for explaining why clustering phages is important for phage therapy. You mentioned in the beginning that your phage couldn’t be used for phage therapy, why is that?

    1. Of course! Since the phage we ended up isolating was an airborne contaminant, that is why it cannot be used in phage therapy. More specifically, all of the research we conducted before the contaminant was found to be in our sample was for the other phage we were trying to isolate, so we don’t have all of the proper information needed to archive a phage for phage therapy.

  4. You mentioned in the beginning that your phage couldn’t be used for phage therapy, why is that?

  5. I really like that you included the diagram for the two different phage life cycles! In what world applications can a phage with a lytic cycle be utilized against bacteria?

    1. Phages with a lytic life cycle are the most effective phages to be used in phage therapy, or in other words, they can most easily lyse their bacterial hosts. So for real-world applications, once phage therapy is more normalized in modern-day medicine, lytic phages will be the most common phages used in phage therapy to treat antibiotic-resistant bacterial infections.

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